OUR CUSTOMERS WORLDWIDE

Almond A, Duus JO. Quantitative conformational analysis of the core region of N-glycans using residual dipolar couplings, aqueous molecular dynamics, and steric alignment. J Biomol NMR. 2001 Aug;20(4):351-63.Hongjun Zhou, Annaleen Vermeulen, Fiona M. Jucker, Arthur Pardi. Incorporating residual dipolar couplings into the NMR solution structure determination of nucleic acids Biopolymers, 2001, 52, is4, 168 - 180 PubMed
Mirko Hennig, Teresa Carlomagno & James R. Williamson (2001) Residual Dipolar Coupling TOCSY for Direct Through Space Correlations of Base Protons and Phosphorus Nuclei in RNA J. Am. Chem. Soc. PDF file
James J. Chou, Shipeng Li, Claude B. Klee and Ad Bax Solution structure of Ca2+–calmodulin reveals flexible hand-like properties of its domains. Nature Struc Biol. 2001 Volume 8 Number 11 pp 990 - 997 PDF file
Markus Zweckstetter and Ad Bax (2001) Characterization of molecular alignment in aqueous suspensions of Pf1 bacteriophage J. Biomol. NMR 20, 365-377.Eike Brunner (2001) Residual dipolar couplings in protein NMR Concepts in Magnetic Resonance 13, 4, p. 238 - 259
Wolfgang Peti, Jens Meiler, Rafael Brueschweiler and Christian Griesinger. (2002) Model-Free Analysis of Protein Backbone Motion from Residual Dipolar Couplings J. AM. CHEM. SOC., 124, 5822-5833Elena Kashuba , Vladimir Kashuba , Tatjana Sandalova , George Klein and Laszlo Szekely (2002) Epstein-Barr virus encoded nuclear protein EBNA-3 binds a novel human uridine kinase/uracil phosphoribosyltransferase, BMC Cell Biology 2002 3: 23, PDF file
Perttu Permi. Intraresidual HNCA: an experiment for correlating only intraresidual backbone resonances. J Biomol NMR. 2002 Jul;23(3):201-9.Tapas K. Mal, Nikolai R. Skrynnikov, Kyoko L. Yap, Lewis E. Kay, and Mitsuhiko Ikura. Detecting Protein Kinase Recognition Modes of Calmodulin by Residual Dipolar Couplings in Solution NMR. Biochemistry Volume 41, Number 43 October 29, 2002 PDF file
Edvards Liepinsh, Catherine Genereux, Dominique Dehareng, Bernard Joris and Gottfried Otting. NMR Structure of Citrobacter freundii AmpD, Comparison with Bacteriophage T7 Lysozyme and Homology with PGRP Domains. J. Mol. Biol. (2003) 327, 833–842 PDF file
Jonathan A. Lukin, Georg Kontaxis, Virgil Simplaceanu, Yue Yuan, Ad Bax and Chien Ho. Quaternary structure of hemoglobin in solution. PNAS, 2003, 100, 517-520 PDF file
David W. Staple and Samuel E. Butcher Solution structure of the HIV-1 frameshift inducing stem–loop RNA Nucleic Acids Research, 2003, Vol. 31, No. 15 4326-4331 PubMedSung-Hun Bae, Hae-Kap Cheong, Chaejoon Cheong, Sukhyun Kang, Deog Su Hwang, and Byong-Seok Choi Structure and Dynamics of Hemimethylated GATC Sites 2003 J Biol Chem, 278, 45987–45993 PDF file
NICHOLAS J. REITER, LAURA J. NIKSTAD, ANNE M. ALLMANN, RANDAL J. JOHNSON and SAMUEL E. BUTCHER Structure of the U6 RNA intramolecular stem–loop harboring an SP-phosphorothioate modification. RNA (2003), 9:533-542.Nicholas J. Skelton, Michael F. T. Koehler, Kerry Zobel, Wai Lee Wong, Sherry Yeh, M. Theresa Pisabarro, Jian Ping Yin, Laurence A. Lasky, and Sachdev S. Sidhu Origins of PDZ Domain Ligand Specificity: STRUCTURE DETERMINATION AND MUTAGENESIS OF THE ERBIN PDZ DOMAIN (2003) J. Biol. Chem., Vol. 278, Issue 9, 7645-7654
Edvards Liepinsh, Catherine Genereux, Dominique Dehareng Bernard Joris and Gottfried Otting NMR Structure of Citrobacter freundii AmpD Comparison with Bacteriophage T7 Lysozyme and Homology with PGRP Domains J. Mol. Biol. (2003) 327, 833–842 PDF file
Kyoko L. Yap, Tao Yuan, Tapas K. Mal, Hans J. Vogel and Mitsuhiko Ikura Structural Basis for Simultaneous Binding of Two Carboxy-terminal Peptides of Plant Glutamate Decarboxylase to Calmodulin J. Mol. Biol. (2003) 328, 193–204 PDF file
Tine Walma, Jan Aelen, Sander B. Nabuurs, Marlies Oostendorp, Lieke van den Berk, Wiljan Hendriks and Geerten W. Vuister. A Closed Binding Pocket and Global Destabilization Modify the Binding Properties of an Alternatively Spliced Form of the Second PDZ Domain of PTP-BL 2004 Structure, 12, 11–20. PDF file
Ghosh M, Elsby LM, Mal TK, Gooding JM, Roberts SG, Ikura M. Probing Zn2+-binding effects on the zinc-ribbon domain of human general transcription factor TFIIB. Biochem J. 2004 Mar 1;378(Pt 2):317-24. Meier S, Haussinger D, Pokidysheva E, Bachinger HP, Grzesiek S. Determination of a high-precision NMR structure of the minicollagen cysteine rich domain from Hydra and characterization of its disulfide bond formation. FEBS Lett. 2004 Jul 2;569(1-3):112-6.
Hudson BP, Martinez-Yamout MA, Dyson HJ, Wright PE. Recognition of the mRNA AU-rich element by the zinc finger domain of TIS11d. Nat Struct Mol Biol. 2004 Mar;11(3):257-64. PubMed
Sigel RK, Sashital DG, Abramovitz DL, Palmer AG, Butcher SE, Pyle AM Solution structure of domain 5 of a group II intron ribozyme reveals a new RNA motif. Nat Struct Mol Biol. 2004 Feb;11(2):187-92. PubMed
Walma, Tine, Jan Aelen, Sander B. Nabuurs, Marlies Oostendorp, Lieke van den Berk, Wiljan Hendriks, and Geerten W. Vuister A Closed Binding Pocket and Global Destabilization Modify the Binding Properties of an Alternatively Spliced Form of the Second PDZ Domain of PTP-BL (2004) Structure, 12, 11–20 PDF file.
Zheng D, Aramini JM, Montelione GT. Validation of helical tilt angles in the solution NMR structure of the Z domain. Protein Sci. 2004; 13: 549-554.Brian P Hudson, Maria A Martinez-Yamout, H Jane Dyson & Peter E Wright. Recognition of the mRNA AU-rich element by the zinc finger domain of TIS11d. Nature Structural & Molecular Biology (2004)11, 257 - 264
Zweckstetter M, Hummer G, Bax A. Prediction of charge-induced molecular alignment of biomolecules dissolved in dilute liquid-crystalline phases. Biophys J. (2004) Jun;86(6):3444-60.Santiveri CM, Perez-Canadillas JM, Vadivelu MK, Allen MD, Rutherford TJ, Watkins NA, Bycroft M. NMR Structure of the alpha-Hemoglobin Stabilizing Protein. J. Biol. Chem.(2004) 279: 34963-34970.
Susan L. Rowland, William F. Burkholder, Katherine A. Cunningham, Mark W. Maciejewski, Alan D. Grossman, and Glenn F. King Structure and Mechanism of Action of Sda, an Inhibitor of the Histidine Kinases that Regulate Initiation of Sporulation in Bacillus subtilis Molecular Cell, Vol. 13, 689–701, March 12, 2004
Christopher P. Jaroniec, Tobias S. Ulmer and Ad Bax Quantitative J correlation methods for the accurate measurement of 13Cprime-13Cagr dipolar couplings in proteins October 2004 Journal of Biomolecular NMR Volume 30, Number 2 p.181 - 194
Jean-Guillaume Renisio, Sylvain Cosquer, Ilham Cherrak, Sai¨d El Antri, Olivier Mauffret and Serge Fermandjian Pre-organized structure of viral DNA at the binding-processing site of HIV-1 integrase Nucleic Acids Research, 2005, Vol. 33, No. 6
Carlos W. Bertoncini, Young-Sang Jung, Claudio O. Fernandez, Wolfgang Hoyer, Christian Griesinger, Thomas M. Jovin, and Markus Zweckstetter 2005 Release of long-range tertiary interactions potentiates aggregation of natively unstructured alpha-synuclein PNAS, 2005, vol. 102 no. 5, p.1430–1435.
Brian E. Coggins, Amanda L. McClerren, Ling Jiang, Xuechen Li, Johannes Rudolph, Ole Hindsgaul Christian R. H. Raetz, and Pei Zhou Refined Solution Structure of the LpxC-TU-514 Complex and pKa Analysis of an Active Site Histidine: Insights into the Mechanism and Inhibitor Design. (2005) Biochemistry 44, 1114-1126
R.K.O.Siegel, D G Sashital, DL Abramovitz, A G PalmerIII, S E Butcher and AM Pyle Solution structure of domain 5 of a group II intron ribozyme reveals a new RNA motif 2004 Nature Structural and Molecular biology 11, No2, 184
Bottomley MJ, Stier G, Pennacchini D, Legube G, Simon B, Akhtar A, Sattler M, Musco G. NMR structure of the first PHD finger of autoimmune regulator protein (AIRE1). Insights into autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) disease. J Biol Chem. 2005 Mar 25;280(12):11505-12
Dames SA, Mulet JM, Rathgeb-Szabo K, Hall MN, Grzesiek S. . The solution structure of the FATC domain of the protein kinase target of rapamycin suggests a role for redox-dependent structural and cellular stability. J Biol Chem. 2005 May 27;280(21):20558-64. Epub 2005 Mar 16
T. C. LEEPER and G. VARANI The structure of an enzyme-activating fragment of human telomerase RNA. RNA 2005, 10.1261/rna.7222505
Bertoncini CW, Jung YS, Fernandez CO, Hoyer W, Griesinger C, Jovin TM, Zweckstetter M. Release of long-range tertiary interactions potentiates aggregation of natively unstructured alpha-synuclein. Proc Natl Acad Sci USA. 2005 Feb 1;102(5):1430-5.
Davis JH, Tonelli M, Scott LG, Jaeger L, Williamson JR, Butcher SE. RNA helical packing in solution: NMR structure of a 30 kDa GAAA tetraloop-receptor complex. J Mol Biol. 2005 Aug 12;351(2):371-82. Erratum in: J Mol Biol. 2006 Jul 14;360(3):742.
Cornish PV, Hennig M, Giedroc DP. A loop 2 cytidine-stem 1 minor groove interaction as a positive determinant for pseudoknot-stimulated -1 ribosomal frameshifting. Proc Natl Acad Sci USA. 2005 Sep 6;102(36):12694-9.
Edwards TA, Butterwick JA, Zeng L, Gupta YK, Wang X, Wharton RP, Palmer AG 3rd, Aggarwal AK. Solution structure of the Vts1 SAM domain in the presence of RNA. J Mol Biol. 2006 Mar 10;356(5):1065-72.
Flodell S, Petersen M, Girard F, Zdunek J, Kidd-Ljunggren K, Schleucher J, Wijmenga S. Solution structure of the apical stem-loop of the human hepatitis B virus encapsidation signal. Nucleic Acids Res. 2006;34(16):4449-57.
Zeeb M, Max KE, Weininger U, Low C, Sticht H, Balbach J. Recognition of T-rich single-stranded DNA by the cold shock protein Bs-CspB in solution. Nucleic Acids Res. 2006;34(16):4561-71. Epub 2006 Sep 6.
Kieken F, Paquet F, Brule F, Paoletti J, Lancelot G. A new NMR solution structure of the SL1 HIV-1Lai loop-loop dimer. Nucleic Acids Res. 2006 Jan 12;34(1):343-52. Print 2006.
R. Wei, J. Schnell, N. Larsen, P. Sorger, J. Chou, S. Harrison. Structure of a Central Component of the Yeast Kinetochore: The Spc24p/Spc25p Globular Domain. Structure, Volume 14, Issue 6, Pages 1003-1009
Srisailam S, Lukin JA, Yee A, Semesi A, Arrowsmith CH. Solution structure of acyl carrier protein from Nitrosomonas europaea. Proteins. 2006 Aug 15;64(3):800-3. Burton RA, Tjandra N. Determination of the residue-specific 15N CSA tensor principal components using multiple alignment media. J Biomol NMR. 2006 Aug;35(4):249-59.
Yamniuk AP, Ishida H, Vogel HJ. The interaction between calcium- and integrin-binding protein 1 and the alphaIIb integrin cytoplasmic domain involves a novel C-terminal displacement mechanism. J Biol Chem. 2006 Sep 8;281(36):26455-64.
Cornish PV, Stammler SN, Giedroc DP. The global structures of a wild-type and poorly functional plant luteoviral mRNA pseudoknot are essentially identical. RNA. 2006 Nov;12(11):1959-69.
Alvarez-Salgado F, Desvaux H, Boulard Y. NMR assessment of the global shape of a non-labelled DNA dodecamer containing a tandem of G-T mismatches. Magn Reson Chem. 2006 Dec;44(12):1081-9.
Zweckstetter M. Prediction of charge-induced molecular alignment: residual dipolar couplings at pH 3 and alignment in surfactant liquid crystalline phases. Eur Biophys J. 2006 Jan;35(2):170-80.
Koskela H, Heikkinen O, Kilpelainen I, Heikkinen S. Rapid and accurate processing method for amide proton exchange rate measurement in proteins. J Biomol NMR. 2007 Apr;37(4):313-20.
Sun X, Zhang Q, Al-Hashimi HM. Resolving fast and slow motions in the internal loop containing stem-loop 1 of HIV-1 that are modulated by Mg2+ binding: role in the kissing-duplex structural transition. Nucleic Acids Res. 2007;35(5):1698-713.
Sashital DG, Venditti V, Angers CG, Cornilescu G, Butcher SE. Structure and thermodynamics of a conserved U2 snRNA domain from yeast and human. RNA. 2007 Mar;13(3):328-38.
Henzl MT, Tanner JJ.Solution structure of Ca2+-free rat beta-parvalbumin (oncomodulin). Protein Sci. 2007 Sep;16(9):1914-26.
Mansy SS, Zhang J, Kümmerle R, Nilsson M, Chou JJ, Szostak JW, Chaput JC. Structure and evolutionary analysis of a non-biological ATP-binding protein. J Mol Biol. 2007 Aug 10;371(2):501-13. Epub 2007 May 26.
Mooij MJ, Drenkard E, Llamas MA, Vandenbroucke-Grauls CM, Savelkoul PH, Ausubel FM, Bitter W. Characterization of the integrated filamentous phage Pf5 and its involvement in small-colony formation. Microbiology. 2007 Jun;153(Pt 6):1790-8.
Getz MM, Andrews AJ, Fierke CA, Al-Hashimi HM. Structural plasticity and Mg2+ binding properties of RNase P P4 from combined analysis of NMR residual dipolar couplings and motionally decoupled spin relaxation. RNA. 2007 Feb;13(2):251-66.
Arthur
Pardi
University of Colorado
CO USA
Arthur.Pardi@Colorado.EDU
G. Marius Clore
NIDDK, National Institutes of Health
E-mail: mariusc@intra.niddk.nih.gov
web: http://spin.niddk.nih.gov/clore
Ad
Bax
National Institutes of Health
Bethesda, MD, USA
bax@nih.gov
http://spin.niddk.nih.gov/bax/
Gottfried
Otting
gottfried.otting@anu.edu.au
Australian National University
Research School of Chemistry
Australia
Magnus
Ingelman-Sundberg
Magnus.Ingelman-Sundberg@imm.ki.se
Karolinska Institute, Institute of Environmental Medicine
Stockholm, SWEDEN
Gregg
Siegal
g.siegal@chem.leidenuniv.nl
Gorlaeus Laboratory
Leiden University
Leiden, The Netherlands
http://chemaef.leidenuniv.nl/~siegal
Masahiro
Shirakawa
shira@bs.aist-nara.ac.jp
Graduate School of Biological Sciences
Nara Institute of Science and Technology
Nara, JAPAN
Masatsune
Kainosho
kainosho@nmr.chem.metro-u.ac.jp
Tokyo Metropolitan University
Tokyo. JAPAN
Magnus
Ingelman-Sundberg
Magnus.Ingelman-Sundberg@imm.ki.se
Karolinska Institute, Institute of Environmental Medicine
Stockholm, SWEDEN
Ingeborg
van der Ploeg
ingplo@ste.ki.se
St. Eriks Eye Hospital Research Department
Stockholm, SWEDEN
Gottfried
Otting
gottfried.otting@anu.edu.au
Australian National University
Research School of Chemistry
Australia
Antibody production
Magnus
Ingelman-Sundberg
Magnus.Ingelman-Sundberg@imm.ki.se
Karolinska Institute, Institute of Environmental Medicine
Stockholm, SWEDEN
Elena
Kashuba Karolinska Institute, Microbiology and Tumorbiology Center
Stockholm, SWEDEN
Participation in EU grants
FP6: BACABC: 2007-2009, coordinated by Xavier Daura, UAB, Spain
FP6: COMPUVAC: 2005-2008, coordinated by D.Klatzmann, CNRS, France